For the barbecue sauce:
1 1/2 cups ketchup
1/2 cup packed dark brown sugar
1/2 cup water
1/4 cup finely chopped yellow onion
3 tablespoons cider vinegar
3 tablespoons Worcestershire sauce
2 chipotles in adobo sauce, finely chopped
1 teaspoon garlic powder
3/4 teaspoon freshly ground black pepper
For the brisket:
1/4 cup paprika
1 tablespoon chili powder
1 tablespoon ground cumin
1 tablespoon packed dark brown sugar
1 tablespoon kosher salt, plus more as needed
1 teaspoon cayenne pepper
1 teaspoon garlic powder
1 teaspoon freshly ground black pepper, plus more as needed
5lb beef brisket